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Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial.

Abstract:

Single low doses of primaquine, when added to artemisinin-based combination therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. We aimed to establish the activity and safety of four low doses of primaquine combined with dihydroartemisinin-piperaquine in male patients in Mali.In this phase 2, single-blind, dose-ranging, adaptive randomised trial, we enrolled boys and men with uncomplicated P falciparum malaria at the Malaria Research and Training Centre (MRTC) f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier Ltd. Publisher's website
Journal:
The Lancet. Infectious diseases Journal website
Volume:
16
Issue:
6
Pages:
674–684
Publication date:
2016-02-20
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:102d67c1-0b3a-4227-a130-7dcd4168841e
Source identifiers:
607275
Local pid:
pubs:607275
Paper number:
6
Language:
English
Keywords:

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