Journal article
Liquidity in immune cell signaling
- Abstract:
- Signaling molecules (blue) form liquid-like phases, instead of static aggregates, in a reconstituted system using an artificial lipid bilayer. Shown is a model of clustered pLAT and associated signaling molecules that phase separate into a liquid-like droplet in response to TCR activation. The cluster induces actin polymerization, which is a solid phase gel that changes the shape of the liquid-like droplet.
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
Actions
Access Document
- Files:
-
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(Preview, Accepted manuscript, pdf, 159.8KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 101.5KB, Terms of use)
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- Publisher copy:
- 10.1126/science.aaf8179
Authors
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science More from this journal
- Volume:
- 352
- Issue:
- 6285
- Pages:
- 516-517
- Publication date:
- 2016-04-29
- DOI:
- EISSN:
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1095-9203
- ISSN:
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0036-8075
- Language:
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English
- Pubs id:
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pubs:619825
- UUID:
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uuid:102cf542-f93e-4bb9-83b1-9fc8f2aa0c9a
- Local pid:
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pubs:619825
- Source identifiers:
-
619825
- Deposit date:
-
2016-05-19
Terms of use
- Copyright holder:
- Dustin and Muller
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright; published by the American Association for the Advancement of Science under license. This is the accepted manuscript version of the article. Substantial changes were made to the article and the figure prior to publication. The final version is available online from the American Association for the Advancement of Science at: 10.1126/science.aaf8179
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