Journal article icon

Journal article

Liquidity in immune cell signaling

Abstract:
Signaling molecules (blue) form liquid-like phases, instead of static aggregates, in a reconstituted system using an artificial lipid bilayer. Shown is a model of clustered pLAT and associated signaling molecules that phase separate into a liquid-like droplet in response to TCR activation. The cluster induces actin polymerization, which is a solid phase gel that changes the shape of the liquid-like droplet.
Publication status:
Published
Peer review status:
Reviewed (other)
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1126/science.aaf8179

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
352
Issue:
6285
Pages:
516-517
Publication date:
2016-04-29
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:102cf542-f93e-4bb9-83b1-9fc8f2aa0c9a
Source identifiers:
619825
Local pid:
pubs:619825
Paper number:
6285
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP