- Abstract:
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BACKGROUND: L-arginine infusion improves endothelial function in malaria but its safety profile has not been described in detail. We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria. METHODOLOGY AND FINDINGS: In an ascending dose study, adjunctive intravenous L-arginine hydrochloride was infused over 30 minutes in doses of 3 g, 6 g and 12 g to three separate groups of 10 adults hos...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 159.4kb)
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- Publisher copy:
- 10.1371/journal.pone.0002347
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- Grant:
- NHMRC ICRG ID 283321
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 3
- Issue:
- 6
- Pages:
- e2347
- Publication date:
- 2008
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:102371fc-3ba7-4290-8b19-808e95261676
- Source identifiers:
-
61485
- Local pid:
- pubs:61485
- Copyright date:
- 2008
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Journal article
Safety profile of L-arginine infusion in moderately severe falciparum malaria.
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Tudor Foundation
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+ National Health and Medical Research Council of Australia
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