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Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial

Abstract:
Background Infant pain has immediate and long-term effects but is undertreated because of a paucity of evidence-based analgesics. Although morphine is often used to sedate ventilated infants, its analgesic efficacy is unclear. We aimed to establish whether oral morphine could provide effective and safe analgesia in non-ventilated premature infants for acute procedural pain.

Methods In this single-centre masked trial, 31 infants at the John Radcliff... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/s0140-6736(18)31813-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
Brasenose College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
The Lancet Journal website
Volume:
392
Issue:
10164
Pages:
2595-2605
Publication date:
2018-11-30
Acceptance date:
2018-08-01
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:951087
URN:
uri:10165730-58b4-4567-aae3-627ff83b7462
UUID:
uuid:10165730-58b4-4567-aae3-627ff83b7462
Local pid:
pubs:951087
Language:
English
Keywords:

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