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Journal article

Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.

Abstract:

The solution structure and stability of N-terminally truncated beta2-microglobulin (deltaN6beta2-m), the major modification in ex vivo fibrils, have been investigated by a variety of biophysical techniques. The results show that deltaN6beta2-m has a free energy of stabilization that is reduced by 2.5 kcal/mol compared to the intact protein. Hydrogen exchange of a mixture of the truncated and full-length proteins at microM concentrations at pH 6.5 monitored by electrospray mass spectrometry re...

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Publication status:
Published

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Publisher copy:
10.1110/ps.9.5.831

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Journal:
Protein science : a publication of the Protein Society
Volume:
9
Issue:
5
Pages:
831-845
Publication date:
2000-05-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:100d124f-0aa2-4aa0-a642-0574ed10d8fa
Source identifiers:
59376
Local pid:
pubs:59376

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