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Journal article

The mammalian endoplasmic reticulum-associated degradation system.

Abstract:

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic proteome and is accordingly endowed with specialized machinery to ensure that proteins deployed to the distal secretory pathway are correctly folded and assembled into native oligomeric complexes. Proteins failing to meet this conformational standard are degraded by ER-associated degradation (ERAD), a complex process through which folding-defective proteins are selected and ultimately degraded by th...

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Publication status:
Published

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Publisher copy:
10.1101/cshperspect.a013185

Authors


Olzmann, JA More by this author
Kopito, RR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Journal:
Cold Spring Harbor perspectives in biology
Volume:
5
Issue:
9
Pages:
a013185-a013185
Publication date:
2013-09-05
DOI:
EISSN:
1943-0264
ISSN:
1943-0264
URN:
uuid:10094d08-dc8c-4566-bd6a-ab89bbfe5d4b
Source identifiers:
367665
Local pid:
pubs:367665

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