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Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.

Abstract:

Dendritic cells (DCs) are important for presenting antigen to T cells, especially naïve T cells. It has recently been shown that blocking the transcription factor, nuclear factor kappa B (NF-kappaB) in human DCs inhibited the mixed leukocyte reaction. The aim of this study was to investigate the effect of blocking NF-kappaB in DCs during presentation of antigen to memory T cells in vitro. Peripheral blood monocytes were differentiated into immature DCs with interleukin-4 (IL-4) and granulocyt...

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Publication status:
Published

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Authors


Calder, VL More by this author
Bondeson, J More by this author
Brennan, FM More by this author
Foxwell, BM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Scandinavian journal of immunology
Volume:
57
Issue:
3
Pages:
261-270
Publication date:
2003-03-05
DOI:
EISSN:
1365-3083
ISSN:
0300-9475
URN:
uuid:10018282-f7a1-4c69-ab00-85ddf49c278b
Source identifiers:
224904
Local pid:
pubs:224904

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