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Human immunodeficiency virus type 1 virological synapse formation in T cells requires lipid raft integrity.

Abstract:

Human immunodeficiency virus type 1 (HIV-1) can spread directly between T cells by forming a supramolecular structure termed a virological synapse (VS). HIV-1 envelope glycoproteins (Env) are required for VS assembly, but their mode of recruitment is unclear. We investigated the distribution of GM1-rich lipid rafts in HIV-1-infected (effector) T cells and observed Env colocalization with polarized raft markers GM1 and CD59 but not with the transferrin receptor that is excluded from lipid raft...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of virology
Volume:
79
Issue:
18
Pages:
12088-12094
Publication date:
2005-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:0ff938a5-e792-471f-8aed-7e6ab8a7a2c7
Source identifiers:
25173
Local pid:
pubs:25173

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