Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose.

Journal article

Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstrate that their inhibition by glucose is mediated by ion channels not previously implicated in central or peripheral glucose sensing: tandem-pore K(+) (K(2P)) channels. Importantly...

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Authors: Burdakov, D; Jensen, LT; Alexopoulos, H; Williams, R; Fearon, I

• Publication status: Published
• Journal: Neuron
• Volume: 50
• Issue: 5
• Pages: 711-722
• Publication date: 2006-06-01
• DOI: 10.1016/j.neuron.2006.04.032
• EISSN: 1097-4199
• ISSN: 0896-6273
• Language: English
• Keywords: Green Fluorescent Proteins; Patch-Clamp Techniques; Neuropeptides; Acids; Animals; Wakefulness; Protein Subunits; Signal Transduction; Potassium Channels, Tandem Pore Domain; Gene Expression; Anesthetics, Inhalation; Mice, Inbred C57BL; Female; Excitatory Postsynaptic Potentials; Glucose; Mice, Transgenic; Neural Inhibition; Intracellular Signaling Peptides and Proteins; Potassium Channels; Energy Metabolism; Halothane; Mice, Inbred DBA; Mice; Neurons