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UDP-glucose dehydrogenase: structure and function of a potential drug target

Abstract:

Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in the present paper, and structure-based sequence comparison is used for subclassification of UGDH family members. The eukaryotic group of enzymes (UGDH-II) utilize an extended C-terminal domain for the f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/BST0381378

Authors


Publisher:
Portland Press Publisher's website
Journal:
Biochemical Society transactions Journal website
Volume:
38
Issue:
5
Pages:
1378-85
Publication date:
2010-01-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:0feec673-8b5f-4961-80ad-982d15edd333
Local pid:
SGC:20863317

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