Biosynthesis of the glycosaminoglycan precursor UDP-α-D-glucuronic acid occurs through a 2-fold oxidation of UDP-α-D-glucose that is catalysed by UGDH (UDP-α-D-glucose 6-dehydrogenase). Structure-function relationships for UGDH and proposals for the enzymatic reaction mechanism are reviewed in the present paper, and structure-based sequence comparison is used for subclassification of UGDH family members. The eukaryotic group of enzymes (UGDH-II) utilize an extended C-terminal domain for the f...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
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- Copyright holder:
- Austrian Science Fund FWF and Egger et al.
- Copyright date:
- Copyright © The Authors Journal compilation © 2010 Biochemical Society.
UDP-glucose dehydrogenase: structure and function of a potential drug target
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