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Transition from long-term nonprogression to HIV-1 disease associated with escape from cellular immune control.

Abstract:

Transition from long-term nonprogressive infection to progressive HIV-1 disease presents an opportunity to investigate pathogenesis in a defined immunogenetic background. We studied a male long-term nonprogressor (LTNP) who remained asymptomatic and viremic and had normal CD4 T-cell counts without antiretroviral therapy for >18 years and then experienced a transition to disease progression. We analyzed the complete HIV-1 genomic RNA sequence from plasma and cellular immune responses to pre...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Volume:
48
Issue:
2
Pages:
119-126
Publication date:
2008-06-05
DOI:
EISSN:
1944-7884
ISSN:
1525-4135
URN:
uuid:0febc4b7-ce28-4fc1-b2c7-6a93c765802b
Source identifiers:
95291
Local pid:
pubs:95291

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