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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Abstract:

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition event leads to intracellular phosphorylation remains unclear. Here, we used single-molecule localization microscopy to quantify the organization of TCR–CD3 complexes into nanoscale clusters and to dist...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1607436113

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Role:
Author
ORCID:
0000-0003-1701-5551
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Role:
Author
ORCID:
0000-0002-8517-4469
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
113
Issue:
37
Pages:
E5454-E5463
Publication date:
2016-08-29
Acceptance date:
2016-07-26
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:641763
URN:
uri:0fe4994d-196f-42bb-8554-06b1473da2d2
UUID:
uuid:0fe4994d-196f-42bb-8554-06b1473da2d2
Local pid:
pubs:641763

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