- Abstract:
-
Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition event leads to intracellular phosphorylation remains unclear. Here, we used single-molecule localization microscopy to quantify the organization of TCR–CD3 complexes into nanoscale clusters and to dist...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1073/pnas.1607436113
-
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- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 113
- Issue:
- 37
- Pages:
- E5454-E5463
- Publication date:
- 2016-08-29
- Acceptance date:
- 2016-07-26
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pubs id:
-
pubs:641763
- URN:
-
uri:0fe4994d-196f-42bb-8554-06b1473da2d2
- UUID:
-
uuid:0fe4994d-196f-42bb-8554-06b1473da2d2
- Local pid:
- pubs:641763
- Language:
- English
- Keywords:
- Copyright holder:
- Pageon et al.
- Copyright date:
- 2016
- Notes:
- Note: an erratum exists for this article, originally published and available at: https://doi.org/10.1073/pnas.1615763113
Journal article
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
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