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Tetrahydrobiopterin in cardiovascular health and disease.

Abstract:

Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies...

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Publication status:
Published

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Publisher copy:
10.1089/ars.2013.5566

Authors


Bendall, JK More by this author
Douglas, G More by this author
McNeill, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Journal:
Antioxidants and redox signaling
Volume:
20
Issue:
18
Pages:
3040-3077
Publication date:
2014-06-05
DOI:
EISSN:
1557-7716
ISSN:
1523-0864
URN:
uuid:0fdfd8c4-6a8e-4821-8c80-b448c9465f9d
Source identifiers:
441670
Local pid:
pubs:441670

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