Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.

Journal article

Interleukin 4 (IL-4) has previously been shown to downregulate the production of proinflammatory cytokines such as TNF-alpha, and hence has been considered to be a potential anti-inflammatory agent. In this study we have investigated the effects of IL-4 on the expression of both p55 and p75 TNF receptors (TNF-R) by flow cytometry and radioligand binding analyses and demonstrate that IL-4 downregulates both p55 and p75 TNF-R on HeLa and Jijoye cell lines in a dose dependent manner. IL-4 reduce...

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Authors: Cope, A; Gibbons, D; Aderka, D; Foxwell, B; Wallach, D

• Publication status: Published
• Journal: Cytokine
• Volume: 5
• Issue: 3
• Pages: 205-212
• Publication date: 1993-05-01
• DOI: 10.1016/1043-4666(93)90006-q
• EISSN: 1096-0023
• ISSN: 1043-4666
• Language: English
• Keywords: Cell Line; Interleukin-4; Hela Cells; Humans; Recombinant Proteins; Knee Joint; Osteoarthritis; Arthritis; Receptors, Tumor Necrosis Factor; Synovial Fluid; Tumor Necrosis Factor-alpha; Cells, Cultured; Monocytes; Arthritis, Rheumatoid; Tumor Cells, Cultured; Down-Regulation; Burkitt Lymphoma; Up-Regulation