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Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.

Abstract:

Interleukin 4 (IL-4) has previously been shown to downregulate the production of proinflammatory cytokines such as TNF-alpha, and hence has been considered to be a potential anti-inflammatory agent. In this study we have investigated the effects of IL-4 on the expression of both p55 and p75 TNF receptors (TNF-R) by flow cytometry and radioligand binding analyses and demonstrate that IL-4 downregulates both p55 and p75 TNF-R on HeLa and Jijoye cell lines in a dose dependent manner. IL-4 reduce...

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Publication status:
Published

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Journal:
Cytokine
Volume:
5
Issue:
3
Pages:
205-212
Publication date:
1993-05-05
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
URN:
uuid:0fd7b8b0-38cc-4aa3-89e8-e0d787ba8e1f
Source identifiers:
481709
Local pid:
pubs:481709

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