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Inferring the effects of cancer treatment: divergent results from early breast cancer trialists' collaborative group meta-analyses of randomized trials and observational data from SEER registries

Abstract:

To compare the effect of breast cancer radiotherapy as estimated from observational data with findings from randomized trials.Rate ratios were obtained for selected end points among 13,932 women randomly assigned to receive radiotherapy or not in trials contributing to recent meta-analyses by the Early Breast Cancer Trialists' Collaborative Group. Estimates of the same quantities were derived for 393,840 women registered with breast cancer in the US SEER registries between 1973 and 2008.In th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1200/jco.2015.62.0294

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Role:
Author
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Cancer Research UK More from this funder
British Heart Foundation More from this funder
Medical Research Council More from this funder
Nuffield Department of Population Health, University of Oxford More from this funder
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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
34
Issue:
8
Pages:
803-809
Publication date:
2016-03-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:0fc7d466-0b54-455c-913d-f9fe9590d8bc
Source identifiers:
598001
Local pid:
pubs:598001
Language:
English

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