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The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.

Abstract:

The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The inhibition of the 26S proteasome by Bortezomib leads to the accumulation of misfolded proteins, resulting in endoplasmic reticulum stress followed by a coordinated cellular response called unfolded protein response (UPR). Endoplasmic reticulum stress is also a potent inducer of macroautophagy. Bortezomib is a selective and potent inhibitor of the 26S proteasome and is approved for the treatment of multipl...

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Publication status:
Published

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Authors


Rzymski, T More by this author
Mellor, HR More by this author
Bottini, A More by this author
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Journal:
Cancer research
Volume:
69
Issue:
10
Pages:
4415-4423
Publication date:
2009-05-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:0fad6eb9-ff0f-405f-9f09-345f38c0d6a1
Source identifiers:
125268
Local pid:
pubs:125268

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