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Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels.

Abstract:

BACKGROUND: Oxidative stress and neurotrophic factors have been implicated in the pathophysiology of bipolar disorder. Our objective was to determine whether plasma glutathione or brain-derived neurotrophic factor (BDNF) levels were abnormal in bipolar disorder and therefore useful as possible biomarkers. METHOD: Blood samples were collected from subsyndromal, medicated bipolar I patients (n = 50), recruited from OXTEXT, University of Oxford, and from 50 matched healthy controls. Total and ox...

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Publication status:
Published

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Publisher copy:
10.1017/s0033291714000014

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Publisher:
Cambridge University Press
Journal:
Psychological medicine
Volume:
44
Issue:
11
Pages:
1-10
Publication date:
2014-01-05
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
URN:
uuid:0fa829fd-0640-441f-b7bf-7c5794b32c08
Source identifiers:
447561
Local pid:
pubs:447561

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