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RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Abstract:

Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) is one of the most common known causes of familial PD. To characterize its effect on astrocytes, we developed a protocol to produce midbrain-patterned astrocytes from human induced pluripotent stem cells (iPSCs) derived from PD LRRK2 G2019S patients and healthy controls. RNA sequencing analysis revealed the downregulation of genes involve...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.nbd.2019.05.006

Authors


Booth, HDE More by this author
Wessely, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
ORCID:
0000-0001-8350-6928
Rinaldi, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
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Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Disease Journal website
Volume:
129
Pages:
56-66
Publication date:
2019-05-11
Acceptance date:
2019-05-10
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Pubs id:
pubs:999080
URN:
uri:0fa53a5d-9516-435d-9d79-89085c8ca170
UUID:
uuid:0fa53a5d-9516-435d-9d79-89085c8ca170
Local pid:
pubs:999080

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