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Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse.

Abstract:

Recently implemented fluorescence imaging techniques, such as total internal reflection fluorescence microscopy and two-photon laser scanning microscopy, have made possible multiscale analysis of the immune response from single molecules in an interface to cells moving in lymphoid tissues and tumors. In this review, we consider components of T cell sensitivity: the immunological synapse, the coordination of migration, and antigen recognition in vivo. Potency, dose, and detection threshold for...

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Publisher copy:
10.1007/978-3-540-93864-4_3

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Current topics in microbiology and immunology
Volume:
334
Pages:
47-70
Publication date:
2009
DOI:
ISSN:
0070-217X
URN:
uuid:0f989db1-12e4-4f61-9e12-8589fc18da2a
Source identifiers:
426296
Local pid:
pubs:426296

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