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Ion mobility-mass spectrometry reveals the influence of subunit packing and charge on the dissociation of multiprotein complexes.

Abstract:

The composition, stoichiometry, and organization of protein complexes can be determined by collision-induced dissociation (CID) coupled to tandem mass spectrometry (MS/MS). The increased use of this approach in structural biology prompts a better understanding of the dissociation mechanism(s). Here we report a detailed investigation of the CID of two dodecameric, heat-stable and toroidally shaped complexes: heat shock protein 16.9 (HSP16.9) and stable protein 1 (SP-1). While HSP16.9 dissociat...

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Publication status:
Published

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Publisher copy:
10.1021/ac101778e

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Journal:
Analytical chemistry
Volume:
82
Issue:
23
Pages:
9702-9710
Publication date:
2010-12-05
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
URN:
uuid:0f985b39-fffa-4f2d-b1d7-26225faf544e
Source identifiers:
93199
Local pid:
pubs:93199

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