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Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene.

Abstract:

The 5q- syndrome is a myelodysplastic syndrome with the 5q deletion as the sole karyotypic abnormality. The human ATX1 homologue (HAH1), encodes a copper-binding protein with a role in antioxidant defence. We have mapped this gene to the 3 Mb critical region of gene loss of the 5q- syndrome within 5q32, flanked by the genes for ADRB2 and IL12B, using gene dosage analysis. Fine physical mapping of the HAH1 gene within this genomic interval was then performed by screening YAC and BAC contigs sp...

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Publication status:
Published

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Publisher copy:
10.1007/s004390051020

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Strickson, AJ More by this author
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Journal:
Human genetics
Volume:
106
Issue:
1
Pages:
127-129
Publication date:
2000-01-05
DOI:
EISSN:
1432-1203
ISSN:
0340-6717
URN:
uuid:0f8b0e1b-2be3-4f2b-9d43-795314d8b863
Source identifiers:
246200
Local pid:
pubs:246200

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