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Journal article

Structure and mechanism of the oestrogen receptor

Abstract:
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.

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Journal:
Biochemical Society Transactions More from this journal
Volume:
31
Issue:
1
Pages:
56-59
Publication date:
2003-02-01
ISSN:
0300-5127


Language:
English
Keywords:
Pubs id:
pubs:317569
UUID:
uuid:0f833750-2354-4764-9d0d-f7ab3405f2fc
Local pid:
pubs:317569
Source identifiers:
317569
Deposit date:
2012-12-19
ARK identifier:

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