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Changes in the hemagglutinin of H5N1 viruses during human infection--influence on receptor binding.

Abstract:

As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present in the upper airway. We have identified receptor-binding changes which emerged d...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2013.08.010

Authors


Childs, RA More by this author
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Journal:
Virology
Volume:
447
Issue:
1-2
Pages:
326-337
Publication date:
2013-12-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:0f80edce-f533-463f-93d4-d96c120ef2c8
Source identifiers:
429304
Local pid:
pubs:429304

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