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Biofunctionalized, ultrathin coatings of cross-linked star-shaped poly(ethylene oxide) allow reversible folding of immobilized proteins.

Abstract:

Dense, ultrathin networks of isocyanate terminated star-shaped poly(ethylene oxide) (PEO) molecules, cross-linked at their chain ends via urea groups, were shown to be extremely resistant to unspecific adsorption of proteins while at the same time suitable for easy biocompatible modification. Application by spin coating offers a simple procedure for the preparation of minimally interacting surfaces that are functionalized by suitable linker groups to immobilize proteins in their native confor...

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Publisher copy:
10.1021/ja0318028

Authors


Amirgoulova, EV More by this author
Ameringer, T More by this author
Röcker, C More by this author
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Journal:
Journal of the American Chemical Society
Volume:
126
Issue:
13
Pages:
4234-4239
Publication date:
2004-04-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:0f6b5faa-65c0-446a-9990-8dd2cc939047
Source identifiers:
280931
Local pid:
pubs:280931

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