Journal article
The interleaved genome
- Abstract:
- Eukaryotic genomes are pervasively transcribed but until recently this noncoding transcription was considered to be simply noise. Noncoding transcription units overlap with genes and genes overlap other genes, meaning genomes are extensively interleaved. Experimental interventions reveal high degrees of interdependency between these transcription units, which have been co-opted as gene regulatory mechanisms. The precise outcome depends on the relative orientation of the transcription units and whether two overlapping transcription events are contemporaneous or not, but generally involves chromatin-based changes. Thus transcription itself regulates transcription initiation or repression at many regions of the genome.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 585.4KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tig.2015.10.006
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Genetics More from this journal
- Volume:
- 32
- Issue:
- 1
- Pages:
- 57-71
- Publication date:
- 2015-11-21
- DOI:
- ISSN:
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0168-9525
- Language:
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English
- Pubs id:
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pubs:587385
- UUID:
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uuid:0f6b0c95-7e1d-4495-89bc-663771df243e
- Local pid:
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pubs:587385
- Source identifiers:
-
587385
- Deposit date:
-
2016-02-22
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2015
- Notes:
- © 2015 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: [10.1016/j.tig.2015.10.006]
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