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Journal article

Maternal diet programs embryonic kidney gene expression.

Abstract:

Human epidemiological data associating birth weight with adult disease suggest that organogenesis is "programmed" by maternal diet. In rats, protein restriction in pregnancy produces offspring with fewer renal glomeruli and higher systemic blood pressures than controls. We tested the hypothesis that maternal diet alters gene expression in the metanephros, the precursor of the definitive mammalian kidney. We demonstrated that maternal low-protein diet initiated when pregnancy starts and mainta...

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Publication status:
Published

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Authors


Welham, SJ More by this author
Journal:
Physiological genomics
Volume:
22
Issue:
1
Pages:
48-56
Publication date:
2005-06-05
DOI:
EISSN:
1531-2267
ISSN:
1094-8341
URN:
uuid:0f62a96d-5216-464a-867f-237e22ddc40c
Source identifiers:
251929
Local pid:
pubs:251929

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