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Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.

Abstract:

BACKGROUND: The activity of the heterodimeric transcription factor hypoxia inducible factor (HIF) is regulated by the post-translational, oxygen-dependent hydroxylation of its α-subunit by members of the prolyl hydroxylase domain (PHD or EGLN)-family and by factor inhibiting HIF (FIH). PHD-dependent hydroxylation targets HIFα for rapid proteasomal degradation; FIH-catalysed asparaginyl-hydroxylation of the C-terminal transactivation domain (CAD) of HIFα suppresses the CAD-dependent subset of...

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Publication status:
Published online

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Publisher copy:
10.1186/1752-0509-4-139

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
BMC systems biology
Volume:
4
Issue:
1
Pages:
139
Chapter number:
ARTN 139
Publication date:
2010-01-05
DOI:
EISSN:
1752-0509
ISSN:
1752-0509
URN:
uuid:0f6250f4-4e46-4a79-938c-8313403b83e7
Source identifiers:
97242
Local pid:
pubs:97242

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