Formal radical cyclization onto benzene rings: a general method and its use in the synthesis of ent-nocardione A.

Journal article

An indirect method is described for effecting radical cyclization onto a benzene ring. Cross-conjugated dienones 6, which are readily prepared from phenols, undergo radical cyclization (6 --> 7 --> 8), and the products (8) are easily aromatized. The method has been applied to the synthesis of ent-nocardione A (21).

Authors: Clive, D; Fletcher, S; Liu, D

• Publication status: Published
• Journal: Journal of organic chemistry
• Volume: 69
• Issue: 10
• Pages: 3282-3293
• Publication date: 2004-05-01
• DOI: 10.1021/jo030364k
• EISSN: 1520-6904
• ISSN: 0022-3263
• Language: English
• Keywords: Molecular Structure; Furans; Naphthoquinones; Cyclization; Free Radicals; Benzene