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Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation.

Abstract:

Protease activity within nascently released human immunodeficiency virus type 1 (HIV-1) particles is responsible for the cleavage of the viral polyproteins Gag and Gag-Pol into their constituent parts, which results in the subsequent condensation of the mature conical core surrounding the viral genomic RNA. Concomitant with viral maturation is a conformational change in the packaged viral RNA from a loosely associated dimer into a more thermodynamically stable form. In this study we used subo...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2008.06.030

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Soheilian, F More by this author
Nagashima, K More by this author
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Journal:
Virology
Volume:
379
Issue:
1
Pages:
152-160
Publication date:
2008-09-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:0f5adcca-5f51-450a-9143-20194b0f6d53
Source identifiers:
228612
Local pid:
pubs:228612

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