Journal article icon

Journal article

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.

Abstract:

Both central obesity and osteoporosis are common findings in states of glucocorticoid excess. In many tissues, including adipose tissue, hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the inter-conversion of active glucocorticoid, cortisol (F) and inactive cortisone (E) and regulates exposure to the glucocorticoid receptor. As such, factors which regulate 11beta-HSD1 are likely to have an important role in adipose tissue and bone physiology. Using primary cultures of human adipos...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.3109/07435800009048591

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Bujalska, I More by this author
Stewart, PM More by this author
Cooper, MS More by this author
Journal:
Endocrine research
Volume:
26
Issue:
4
Pages:
711-722
Publication date:
2000-11-05
DOI:
EISSN:
1532-4206
ISSN:
0743-5800
URN:
uuid:0f4bacf1-b55e-4afb-a1b0-c8c22a9bd388
Source identifiers:
126339
Local pid:
pubs:126339

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP