Both central obesity and osteoporosis are common findings in states of glucocorticoid excess. In many tissues, including adipose tissue, hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the inter-conversion of active glucocorticoid, cortisol (F) and inactive cortisone (E) and regulates exposure to the glucocorticoid receptor. As such, factors which regulate 11beta-HSD1 are likely to have an important role in adipose tissue and bone physiology. Using primary cultures of human adipos...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.
If you are the owner of this record, you can report an update to it here: Report update to this record