The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis.

Journal article

Both central obesity and osteoporosis are common findings in states of glucocorticoid excess. In many tissues, including adipose tissue, hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the inter-conversion of active glucocorticoid, cortisol (F) and inactive cortisone (E) and regulates exposure to the glucocorticoid receptor. As such, factors which regulate 11beta-HSD1 are likely to have an important role in adipose tissue and bone physiology. Using primary cultures of human adipos...

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Authors: Tomlinson, J; Bujalska, I; Stewart, P; Cooper, MS

• Publication status: Published
• Journal: Endocrine research
• Volume: 26
• Issue: 4
• Pages: 711-722
• Publication date: 2000-11-01
• DOI: 10.3109/07435800009048591
• EISSN: 1532-4206
• ISSN: 0743-5800
• Language: English
• Keywords: Tumor Necrosis Factor-alpha; Cells, Cultured; Obesity; NADP; Skin; Humans; Insulin-Like Growth Factor I; Osteoporosis; Omentum; Bone and Bones; Isoenzymes; Stem Cells; RNA, Messenger; Hydroxysteroid Dehydrogenases; Osteoblasts; Adipocytes; 11-beta-Hydroxysteroid Dehydrogenases