Does senile impairment of cholinergic system in rats concern only disturbances in cholinergic phenotype or the progressive degeneration of neuronal cell bodies?

Journal article

The trophic effect of continuous intraventricular infusion of nerve growth factor (NGF) on morphology of the basal forebrain (BF) cholinergic neurons was tested in 4- and 28-month-old male Wistar rats. All studies were conducted using behaviorally uncharacterized animals from the same breeding colony. Immunohistochemical procedure for choline acetyltransferase (ChAT) and p75NTR receptor has been applied to identify cholinergic cells in the structures of basal forebrain (BF). Using a quantitat...

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Authors: Niewiadomska, G; Wyrzykowska, J; Chechłacz, M

• Journal: Acta biochimica Polonica
• Volume: 47
• Issue: 2
• Pages: 313-330
• Publication date: 2000-01-01
• EISSN: 1734-154X
• ISSN: 0001-527X
• Language: English
• Keywords: Choline O-Acetyltransferase; Infusions, Parenteral; Male; Neurons; Cerebral Ventricles; Limbic System; Rats; Organ Specificity; Receptors, Nerve Growth Factor; Prosencephalon; Nerve Growth Factor; Cerebral Cortex; Rats, Wistar; Aging; Substantia Innominata; Animals