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G1 checkpoint establishment in vivo during embryonic liver development.

Abstract:

BACKGROUND: The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from an extremely short G1 cell phase and lacking G1 checkpoint to lengthening G1 phase and the establishment of the G1 checkpoint. However, the regulatory mechanisms governing these transitions are not well understood. In this study, pregnant mice were exposed to ionizing radiatio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/1471-213x-14-23

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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC developmental biology Journal website
Volume:
14
Issue:
1
Pages:
23
Publication date:
2014-05-19
DOI:
EISSN:
1471-213X
ISSN:
1471-213X
URN:
uuid:0f3ff5e1-7a05-4b73-ba6c-8e82a536fe0b
Source identifiers:
469151
Local pid:
pubs:469151

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