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An acetylcholinesterase-derived peptide inhibits endocytic membrane activity in a human metastatic breast cancer cell line.

Abstract:

Acetylcholinesterase (AChE) is well established as having non-cholinergic functions and is also expressed in breast tumours where its function(s) is not known. Recently, a candidate peptide sequence towards the C-terminal of the AChE molecule has been identified, as the salient site remote from normal catalysis in neurons, and possibly other cells. The main aim of this study was to explore the possibility that 'AChE-peptide' might also affect human breast cancer cells. Uptake of the non-cytot...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1760
Issue:
3
Pages:
415-420
Publication date:
2006-03-05
DOI:
ISSN:
0006-3002
URN:
uuid:0f31d0ae-63c6-4116-8f36-46dcd65bd34d
Source identifiers:
185225
Local pid:
pubs:185225

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