Suppression of insulin secretion by falling plasma glucose levels is impaired in type 2 diabetes.

Journal article

The ability of Type 2 diabetic patients to suppress islet B-cell secretion in response to falling plasma glucose levels has been studied with two different protocols. (1) Five diet-treated diabetic patients and 6 normal subjects were studied after the termination of a hyperglycaemic clamp at 15 mmol l-1 for 150 min, with the plasma glucose levels then being allowed to fall and the glucose clamp re-established at 10 mmol l-1. The plasma insulin levels fell in normal subjects from 178 +/- 141 (+/- SD) mU l-1 at the end of the 15 mmol l-1 clamp to 147 +/- 97 mU l-1 (p less than 0.02) 20 min later, whereas in diabetic patients there was no significant change from 61 +/- 41 to 56 +/- 35 mU l-1, respectively (NS). (2) The second study was performed to assess the turn-off of islet B-cell secretion with diabetic patients and normal subjects starting at comparable plasma insulin levels. Twelve diet-treated diabetic patients and 11 normal subjects were given a continuous low-dose glucose infusion for 60 min at a rate of 5 mg kg-1 ideal body weight min-1, after which the infusion was turned off and the plasma glucose level allowed to fall.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors: Hosker, J; Burnett, M; Matthews, DR; Turner, R

• Publication status: Published
• Journal: Diabetic medicine : a journal of the British Diabetic Association
• Volume: 5
• Issue: 9
• Pages: 856-860
• Publication date: 1988-12-01
• DOI: 10.1111/j.1464-5491.1988.tb01124.x
• EISSN: 1464-5491
• ISSN: 0742-3071
• Language: English
• Keywords: Diabetes Mellitus, Type 2; Reference Values; Humans; Middle Aged; Fasting; Insulin; Blood Glucose; Adult; Glucose Clamp Technique