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Journal article

Assembly reflects evolution of protein complexes.

Abstract:

A homomer is formed by self-interacting copies of a protein unit. This is functionally important, as in allostery, and structurally crucial because mis-assembly of homomers is implicated in disease. Homomers are widespread, with 50-70% of proteins with a known quaternary state assembling into such structures. Despite their prevalence, their role in the evolution of cellular machinery and the potential for their use in the design of new molecular machines, little is known about the mechanisms ...

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Publication status:
Published

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Publisher copy:
10.1038/nature06942

Authors


Boeri Erba, E More by this author
Robinson, CV More by this author
Teichmann, SA More by this author
Journal:
Nature
Volume:
453
Issue:
7199
Pages:
1262-1265
Publication date:
2008-06-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0f2a8a79-d0a1-49f2-980f-648ad66ea8f1
Source identifiers:
59314
Local pid:
pubs:59314

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