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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

Abstract:

We have previously shown that ASPP1 and ASPP2 are specific activators of p53; one mechanism by which wild-type p53 is tolerated in human breast carcinomas is through loss of ASPP activity. We have further shown that 53BP2, which corresponds to a C-terminal fragment of ASPP2, acts as a dominant negative inhibitor of p53 (ref. 1). Hence, an inhibitory form of ASPP resembling 53BP2 could allow cells to bypass the tumor-suppressor functions of p53 and the ASPP proteins. Here, we characterize such...

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Publication status:
Published

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Publisher copy:
10.1038/ng1070

Authors


Bergamaschi, D More by this author
Samuels, Y More by this author
O'Neil, NJ More by this author
Trigiante, G More by this author
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Journal:
Nature genetics
Volume:
33
Issue:
2
Pages:
162-167
Publication date:
2003-02-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:0f2262a4-0f4a-4ae5-813a-532e5ea5cc60
Source identifiers:
83957
Local pid:
pubs:83957

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