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Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.

Abstract:

Wound-associated fibrosis is important to provide tensile strength upon wound healing but at the same time is detrimental to proper tissue regeneration. To date, there is no clear evidence of the role of macrophages and their subpopulations in the control of the kinetics of collagen production during wound healing. To evaluate in vivo the contribution of macrophages in collagen transcription, we depleted macrophages after wounding luciferase reporter mice of the collagen 1 alpha 2 (Col 1α2) p...

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Publication status:
Published

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Publisher copy:
10.1111/exd.12068

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Experimental dermatology
Volume:
22
Issue:
2
Pages:
143-145
Publication date:
2013-02-05
DOI:
EISSN:
1600-0625
ISSN:
0906-6705
URN:
uuid:0f1dccd1-b316-4bb8-80b1-2731063b4d01
Source identifiers:
375799
Local pid:
pubs:375799

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