Journal article

One-pot sulfonamide synthesis exploiting the palladium-catalyzed sulfination of aryl iodides

Abstract:: Aryl ammonium sulfinates, conveniently prepared from aryl iodides and the sulfur dioxide surrogate DABSO, under the action of a Pd(0) catalyst, are transformed in a onepot process to a variety of functionalized sulfonamides. The sulfinate to sulfonamide transformation is achieved by simple treatment with an aqueous solution of the relevant amine and sodium hypochlorite (bleach). A broad range of amines, including anilines, and amino acids derivatives, are combined efficiently with a variety of aryl iodides, leading to sulfonamides in high yields.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Flegeau, E., Harrison, J., & Willis, M. (2015). One-pot sulfonamide synthesis exploiting the palladium-catalyzed sulfination of aryl iodides. SYNLETT, 27(1), 101–105.

MLA Style

Flegeau, E., et al. “One-Pot Sulfonamide Synthesis Exploiting the Palladium-Catalyzed Sulfination of Aryl Iodides.” SYNLETT, vol. 27, no. 1, Thieme, 2015, pp. 101–05.

Chicago Style

Flegeau, E, J Harrison, and M Willis. 2015. “One-Pot Sulfonamide Synthesis Exploiting the Palladium-Catalyzed Sulfination of Aryl Iodides.” SYNLETT 27 (1): 101–5.
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Files:: Flegeau-Harrison-and-Willis.pdf

(Preview, Version of record, pdf, 219.4KB, Terms of use)

Publisher copy:: 10.1055/s-0035-1560578

Authors

+ Flegeau, E More by this author

Role:: Author

+ Harrison, J More by this author

Role:: Author

+ Willis, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Engineering and Physical Sciences Research Council More from this funder

Publisher:: Thieme
Journal:: SYNLETT More from this journal
Volume:: 27
Issue:: 1
Pages:: 101-105
Publication date:: 2015-10-13
Acceptance date:: 2015-09-25
DOI:: 10.1055/s-0035-1560578
EISSN:: 1437-2096
ISSN:: 0936-5214

Keywords:: sulfonamides

sulfinates

aryl halides

amines

palladium catalysis
Pubs id:: pubs:592480
UUID:: uuid:0f18a0aa-1e8e-4bd1-85c3-17e74f90e262
Local pid:: pubs:592480
Source identifiers:: 592480
Deposit date:: 2016-03-11

Terms of use

Copyright holder:: © Georg Thieme Verlag
Copyright date:: 2015
Notes:: © Georg Thieme Verlag Stuttgart. Available under a Creative Commons CC/BY Licence.

Licence:: CC Attribution (CC BY)

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