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Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy.

Abstract:

1-[(2-adamantyl)amino]acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride (PKF275-055), a vildagliptin analog, is a novel, selective, potent, orally bioavailable, and long-acting dipeptidyl peptidase IV inhibitor. We studied the effect of PKF275-055 administration on the prevention, protection, and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. PKF275-055 improved body and muscle weight. Oral glucose tolerance tests showed a marked improvement in glucose metabolism...

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Publisher copy:
10.1124/jpet.111.181529

Authors


Bianchi, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Porretta-Serapiglia, C More by this author
Oggioni, N More by this author
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Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
340
Issue:
1
Pages:
64-72
Publication date:
2012-01-05
DOI:
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:0ef7ce2f-6505-46ea-97b8-6f79099c009c
Source identifiers:
470788
Local pid:
pubs:470788

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