Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.

Journal article

Abstract:: Carbonyl groups are frequently found in endogenous or xenobiotic compounds. Reactive carbonyls, formed during lipid peroxidation or food processing, and xenobiotic quinones are able to covalently modify DNA or amino acids. They can also promote oxidative stress, the products of which are thought to be an important initiating factor in degenerative diseases or cancer. Carbonyl groups are reduced by an array of distinct NADPH-dependent enzymes, belonging to several oxidoreductase families. Thes...
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Journal:: Annual review of pharmacology and toxicology More from this journal
Volume:: 47
Issue:: 1
Pages:: 293-322
Publication date:: 2007-01-01
DOI:: 10.1146/annurev.pharmtox.47.120505.105316
EISSN:: 1545-4304
ISSN:: 0362-1642

Language:: English
Keywords:: Structure-Activity Relationship

Oxidative Stress

Quinones

Mammals

NADH, NADPH Oxidoreductases

Humans

Xenobiotics

Animals

Alcohol Oxidoreductases
Pubs id:: pubs:108625
UUID:: uuid:0edb6b66-4ed6-4d7a-9131-c8ad770821ce
Local pid:: pubs:108625
Source identifiers:: 108625
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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