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Induction of immunological tolerance/hyporesponsiveness in baboons with a nondepleting CD4 antibody.

Abstract:

Tolerance induction with anti-CD4 Abs is well established in rodent transplant and autoimmune disease models, but has yet to be demonstrated in non-human primates or in clinical studies. In retrospect, failure of anti-CD4 Abs to induce tolerance in primates may be technical, a consequence of insufficient dosing and Ab properties influencing immunogenicity and cell depletion. To circumvent these possible limitations, we constructed a novel anti-CD4 mAb, TRX1, humanized to reduce immunogenicity...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.173.7.4715

Authors


Winsor-Hines, D More by this author
Merrill, C More by this author
O'Mahony, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
173
Issue:
7
Pages:
4715-4723
Publication date:
2004-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:0ec95940-7ed1-4cc5-ae45-5b9f790ffe1f
Source identifiers:
23010
Local pid:
pubs:23010

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