Journal article icon

Journal article

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Abstract:

Stat3 is hyperactivated in many human tumors and represents a valid target for anticancer drug design. We present a novel small-molecule Stat3 inhibitor, S3I-M2001, and describe the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 inhibitor. S3I-M2001 is an oxazole-based peptidomimetic of the Stat3 Src homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Cons...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/cb7001973

Authors


Siddiquee, KA More by this author
Gunning, PT More by this author
Expand authors...
Journal:
ACS chemical biology
Volume:
2
Issue:
12
Pages:
787-798
Publication date:
2007-12-05
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
URN:
uuid:0ec68309-a3ac-450f-8552-8f72f965d89c
Source identifiers:
117673
Local pid:
pubs:117673
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP