Journal article
Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31.
- Abstract:
-
1. The ATP-sensitive potassium channel (K(ATP)) of pancreatic beta-cells is composed of the sulphonylurea-binding protein, SUR1, and the inwardly rectifying K(+) channel subunit, Kir6.2. We have characterized two novel isoforms of rat SUR1 in the RINm5F insulin-secreting cell line. 2. SUR1A2 is an allelic variant with a single amino acid change in the first nucleotide-binding domain. Coinjection of SUR1A2 plus Kir6.2 into Xenopus oocytes or expression of a SUR1A2-Kir6.2 tandem in HEK-293 cell...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/sj.bjp.0704836
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Authors
Bibliographic Details
- Journal:
- British journal of pharmacology
- Volume:
- 137
- Issue:
- 1
- Pages:
- 98-106
- Publication date:
- 2002-09-01
- DOI:
- EISSN:
-
1476-5381
- ISSN:
-
0007-1188
- Source identifiers:
-
114533
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:114533
- UUID:
-
uuid:0ec367e3-4da4-4d3b-9bb2-69889e4e67fc
- Local pid:
- pubs:114533
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2002
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