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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

Abstract:

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible for hereditary leiomyomatosis and renal-cell cancer (HLRCC)1. It has previously been demonstrated that the absence of FH leads to the accumulation of fumarate, which activates hypoxia-inducible factors (HIFs) at normal oxygen tensions2-4. However, so far no mechanism that explains the ability of cells to survive without...

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Publisher copy:
10.1038/nature10363

Authors


Rajagopalan, KN More by this author
MacKenzie, ED More by this author
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Journal:
Nature
Volume:
477
Issue:
7363
Pages:
225-228
Publication date:
2011-09-08
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:0ebe39fa-a66f-4b75-ad32-23f077549070
Source identifiers:
179807
Local pid:
pubs:179807
Language:
English

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