Velocity corrected ion extraction in microscope mode imaging mass spectrometry

Journal article

Microscope mode imaging mass spectrometry requires that ions created in a desorption process are focussed both spatially and according to their mass-to-charge ratio, m/z, onto the plane of an imaging detector. However, it is generally difficult to find techniques that optimize both of these parameters simultaneously. The use of pulsed electric fields allows a second order focussing of the ions according to their m/z value, whilst limiting the loss of spatial resolution, albeit over a limited mass range. Here we present a simple method for rescaling the parameters in a pulsed extraction experiment in order to access different mass ranges, whilst still achieving the benefits of simultaneous optimization of mass and spatial resolutions. © 2013 Elsevier B.V.

Authors: Winter, B; Halford, E; Brouard, M

• Publication status: Published
• Journal: INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
• Volume: 356
• Pages: 14-23
• Publication date: 2013-12-15
• DOI: 10.1016/j.ijms.2013.09.012
• ISSN: 1387-3806
• Language: English
• Keywords: Microscope mode; Imaging mass spectrometry; PEDA