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Journal article

MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability.

Abstract:

As well as providing a structural framework, the actin cytoskeleton plays integral roles in cell death, survival, and proliferation. The disruption of the actin cytoskeleton results in the activation of the c-Jun N-terminal kinase (JNK) stress-activated protein kinase (SAPK) pathway; however, the sensor of actin integrity that couples to the JNK pathway has not been characterized in mammalian cells. We now report that the mammalian Ste20-like (MST) kinases mediate the activation of the JNK pa...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.00116-09

Authors


Densham, RM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Anderson, K More by this author
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Journal:
Molecular and cellular biology
Volume:
29
Issue:
24
Pages:
6380-6390
Publication date:
2009-12-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:0eae2efe-369a-4ea7-81a8-6772278bdde3
Source identifiers:
131112
Local pid:
pubs:131112

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