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SERS-melting: a new method for discriminating mutations in DNA sequences.

Abstract:

The reliable discrimination of mutations, single nucleotide polymorphisms (SNPs), and other differences in genomic sequence is an essential part of DNA diagnostics and forensics. It is commonly achieved using fluorescently labeled DNA probes and thermal gradients to distinguish between the matched and mismatched DNA. Here, we describe a novel method that uses surface enhanced (resonance) Raman spectroscopy (SER(R)S) to follow denaturation of dsDNA attached to a structured gold surface. This d...

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Publication status:
Published

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Publisher copy:
10.1021/ja805517q

Authors


Mahajan, S More by this author
Richardson, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Bartlett, PN More by this author
Journal:
Journal of the American Chemical Society
Volume:
130
Issue:
46
Pages:
15589-15601
Publication date:
2008-11-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:0e987ea8-d94f-4231-a147-25ae35724fc6
Source identifiers:
400014
Local pid:
pubs:400014

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