- Abstract:
-
The reliable discrimination of mutations, single nucleotide polymorphisms (SNPs), and other differences in genomic sequence is an essential part of DNA diagnostics and forensics. It is commonly achieved using fluorescently labeled DNA probes and thermal gradients to distinguish between the matched and mismatched DNA. Here, we describe a novel method that uses surface enhanced (resonance) Raman spectroscopy (SER(R)S) to follow denaturation of dsDNA attached to a structured gold surface. This d...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/ja805517q
-
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- Journal:
- Journal of the American Chemical Society
- Volume:
- 130
- Issue:
- 46
- Pages:
- 15589-15601
- Publication date:
- 2008-11-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- URN:
-
uuid:0e987ea8-d94f-4231-a147-25ae35724fc6
- Source identifiers:
-
400014
- Local pid:
- pubs:400014
- Copyright date:
- 2008
Journal article
SERS-melting: a new method for discriminating mutations in DNA sequences.
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