- Abstract:
-
Inhibition of NK and effector T-cell functions and activation of regulatory cell populations are the main immunosuppressive effects of indoleamine-2,3-dioxygenase1 (IDO1). By converting tryptophan (Trp) into kynurenine (Kyn), IDO1 is involved in the immune response homeostasis, and its dysregulated expression is described in immune-related pathologies, as tumors that hijack it to evade immune destruction. Thereby, IDO1 inhibitors are being developed to stimulate antitumor immune responses. Ex...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1177/2472555217712659
-
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- Grant:
- Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
- Grant:
- Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
- Grant:
- Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
- Publisher:
- SAGE Publisher's website
- Journal:
- SLAS DISCOVERY: Advancing Life Sciences R&D Journal website
- Volume:
- 22
- Issue:
- 10
- Pages:
- 1182-1192
- Publication date:
- 2017-05-30
- DOI:
- EISSN:
-
2472-5560
- ISSN:
-
2472-5552
- Pubs id:
-
pubs:809047
- URN:
-
uri:0e83c18c-cd5c-4dff-b3a4-3faf463ce189
- UUID:
-
uuid:0e83c18c-cd5c-4dff-b3a4-3faf463ce189
- Local pid:
- pubs:809047
- Paper number:
- 10
- Language:
- English
- Keywords:
- Copyright holder:
- Society for Laboratory Automation and Screening
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Society for Laboratory
Automation and Screening.
Journal article
Microenvironment tumor metabolic interactions highlighted by qMSI: Application to the tryptophan-kynurenine pathway in immuno-oncology
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+ BPI France
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