Journal article icon

Journal article

Microenvironment tumor metabolic interactions highlighted by qMSI: Application to the tryptophan-kynurenine pathway in immuno-oncology

Abstract:

Inhibition of NK and effector T-cell functions and activation of regulatory cell populations are the main immunosuppressive effects of indoleamine-2,3-dioxygenase1 (IDO1). By converting tryptophan (Trp) into kynurenine (Kyn), IDO1 is involved in the immune response homeostasis, and its dysregulated expression is described in immune-related pathologies, as tumors that hijack it to evade immune destruction. Thereby, IDO1 inhibitors are being developed to stimulate antitumor immune responses. Ex...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1177/2472555217712659

Authors


Ait-Belkacem, R More by this author
Schramme, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
ORCID:
0000-0002-4995-3270
Expand authors...
More from this funder
Grant:
Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
More from this funder
Grant:
Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
More from this funder
Grant:
Tumor Microenvironment Characterization and Applications in Immuno-oncology (A1408004N)
Wallonia Region More from this funder
Publisher:
SAGE Publisher's website
Journal:
SLAS DISCOVERY: Advancing Life Sciences R&D Journal website
Volume:
22
Issue:
10
Pages:
1182-1192
Publication date:
2017-05-30
DOI:
EISSN:
2472-5560
ISSN:
2472-5552
Pubs id:
pubs:809047
URN:
uri:0e83c18c-cd5c-4dff-b3a4-3faf463ce189
UUID:
uuid:0e83c18c-cd5c-4dff-b3a4-3faf463ce189
Local pid:
pubs:809047
Paper number:
10
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP