Metabolic regulation via enzyme filamentation

Journal article

Abstract:: Determining the mechanisms of enzymatic regulation is central to the study of cellular metabolism. Regulation of enzyme activity via polymerization-mediated strategies has been shown to be widespread, and plays a vital role in mediating cellular homeostasis. In this review, we begin with an overview of the filamentation of CTP synthase, which forms filamentous structures termed cytoophidia. We then highlight other important examples of the phenomenon. Moreover, we discuss recent data relating to the regulation of enzyme activity by compartmentalization into cytoophidia. Finally, we hypothesize potential roles for enzyme filament formation in the regulation of metabolism, development and disease.

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Publisher:: Taylor and Francis
Journal:: Critical Reviews in Biochemistry and Molecular Biology More from this journal
Volume:: 51
Issue:: 4
Pages:: 282-293
Publication date:: 2016-04-20
Acceptance date:: 2016-03-28
DOI:: 10.3109/10409238.2016.1172555
EISSN:: 1549-7798
ISSN:: 1040-9238

Keywords:: IMP dehydrogenase

intracellular compartmentation

cytoophidium

CTP synthase

metabolism
Pubs id:: pubs:613094
UUID:: uuid:0e708519-0fc9-4918-80ed-3c7bf92df926
Local pid:: pubs:613094
Source identifiers:: 613094
Deposit date:: 2016-04-04
ARK identifier:: ark:/29072/ora_0e7085190fc9491880ed3c7bf92df926

Copyright holder:: Aughey and Liu
Notes:: Copyright © 2016 The Authors. Published by Informa UK Limited, trading as Taylor & Francis Group.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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