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Journal article

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes.

Abstract:

Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease. LDL particles are removed from the blood by a process known as receptor-mediated endocytosis, which occurs mainly in the liver. A series of classical experiments delineated the major steps in the endocytotic process; apolipoprotein B-100 present on LDL particles binds to a specific receptor (LDL receptor, LDL-R) in specialized areas of...

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Publication status:
Published

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Publisher copy:
10.1007/s11538-008-9347-9

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Journal:
Bulletin of mathematical biology
Volume:
70
Issue:
8
Pages:
2303-2333
Publication date:
2008-11-05
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
URN:
uuid:0e63780e-26c2-493e-bba7-d1fb029ab912
Source identifiers:
319107
Local pid:
pubs:319107

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